Psychotherapy as Epigenetic Medicine: A Commentary on Emerging Evidence
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Farzanegan’s (2022) editorial introduces the concept of psychotherapy as “epigenetic medicine,” proposing that therapeutic interventions can modify underlying mental and cultural patterns (“memes”) with potential biological effects. This commentary contextualizes the editorial within current research on epigenetic mechanisms and neuroplasticity in mental health treatment. Evidence indicates that epigenetic processes influence gene expression and neuroplasticity, contributing to recovery from mood disorders and major depression. Psychotherapy has also been associated with measurable epigenetic changes, although variability across therapeutic modalities presents challenges for empirical investigation. While preliminary findings are promising, further research is needed to identify specific epigenetic biomarkers corresponding to distinct psychotherapeutic interventions. Bridging psychotherapy, neuroscience, and molecular biology could advance mechanistic understanding and improve clinical outcomes.
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